Lamivudine and Zidovudine Tablets and Naproxen Tablets
Determining the interaction of Lamivudine and Zidovudine Tablets and Naproxen Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using zidovudine together with naproxen may increase the risk of bleeding in HIV-positive patients with hemophilia. However, the interaction is not fully understood, and evidence is limited. Talk to your doctor or pharmacist if you have any concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited clinical data suggest that the concomitant use of zidovudine with nonsteroidal anti-inflammatory agents may increase the risk of hematological toxicity and/or bleeding in HIV-positive patients with hemophilia. The mechanism is unknown.
MANAGEMENT: It is recommended to monitor patients for side effects and bleeding during concomitant use.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21
- Sahai J, Gallicano K, Conway B, et al. "Lack of pharmacokinetic interaction between naproxen (N) and zidovudine (Z)." Clin Pharmacol Ther 51 (1992): 184
- Sahai J, Gallicano K, Garber G, et al. "Evaluation of the in vivo effect of naproxen on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus." Clin Pharmacol Ther 52 (1992): 464-70
- Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60
Generic Name: lamivudine / zidovudine
Brand name: Combivir
Synonyms: Lamivudine and zidovudine, Lamivudine and Zidovudine
Generic Name: naproxen
Brand name: Aleve, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan, Naprosyn, Anaprox, Anaprox-DS, Naproxen Sodium, Aleve Caplet, Aleve Gelcap, Aleve Easy Open Arthritis, Naprelan 375, Naprelan 500, Flanax
Synonyms: Naproxen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lamivudine and Zidovudine Tablets-Naproxen Tablets and Capsules
- Lamivudine and Zidovudine Tablets-Naratriptan
- Lamivudine and Zidovudine Tablets-Naratriptan Hydrochloride
- Lamivudine and Zidovudine Tablets-Narcan
- Lamivudine and Zidovudine Tablets-Narcan nasal
- Lamivudine and Zidovudine Tablets-Narcan Nasal Spray
- Naproxen Tablets-Lamivudine Oral Solution
- Naproxen Tablets-Lamivudine Tablets
- Naproxen Tablets-Lamotrigine
- Naproxen Tablets-Lamotrigine Chewable Dispersible Tablets
- Naproxen Tablets-Lamotrigine Chewable Tablet
- Naproxen Tablets-Lamotrigine Extended Release Tablet