Lamotrigine Chewable Dispersible Tablets and Olanzapine, Olanzapine Pamoate
Determining the interaction of Lamotrigine Chewable Dispersible Tablets and Olanzapine, Olanzapine Pamoate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with olanzapine may slightly decrease the plasma concentrations of lamotrigine. The mechanism of interaction has not been described. In 16 healthy male volunteers, addition of olanzapine (15 mg once daily) decreased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of lamotrigine (200 mg once daily) by 20% and 24%, respectively, compared to administration of lamotrigine alone in 12 healthy male volunteers. These alterations are unlikely to be of clinical significance. In another study, olanzapine 5 mg had no effect on the Cmax and AUC of lamotrigine (25 mg daily for 5 days, then 50 mg daily for 13 days) in 14 healthy volunteers, but significantly increased the mean time to reach peak plasma concentration (Tmax) of lamotrigine from 1.9 to 4.0 hours. This effect may be attributable to the anticholinergic properties of olanzapine. Mild sedation was the only adverse effect reported during lamotrigine and olanzapine coadministration. Lamotrigine has no effect on the pharmacokinetics of olanzapine.
- "Product Information. Lamictal (lamotrigine)." Glaxo Wellcome, Research Triangle Park, NC.
- Jann MW, Hon YY, Shamsi SA, Zheng J, Awad EA, Spratlin V "Lack of pharmacokinetic interaction between lamotrigine and olanzapine in healthy volunteers." Pharmacotherapy 26 (2006): 627-33
Generic Name: lamotrigine
Brand name: Lamictal, Lamictal ODT, Lamictal XR, Subvenite, Lamictal CD, LaMICtal Starter Kit, LaMICtal ODT Patient Titration Kit, LaMICtal XR Patient Titration Kit, LamoTRIgine Starter Kit, Subvenite Starter Kit, Lamictal, Lamictal ODT, Lamictal XR
Synonyms: Lamotrigine, LamoTRIgine
Generic Name: olanzapine
Brand name: Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular, Zyprexa Relprevv
Synonyms: Olanzapine, OLANZapine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Lamotrigine Chewable Dispersible Tablets-Olaratumab Intravenous
- Lamotrigine Chewable Dispersible Tablets-Oleptro
- Olanzapine, Olanzapine Pamoate-Lamotrigine Chewable Tablet
- Olanzapine, Olanzapine Pamoate-Lamotrigine Extended Release Tablet
- Olanzapine, Olanzapine Pamoate-Lamotrigine Extended-Release Tablets
- Olanzapine, Olanzapine Pamoate-Lamotrigine ODT
- Olanzapine, Olanzapine Pamoate-Lamotrigine Orally Disintegrating Tablets
- Olanzapine, Olanzapine Pamoate-Lamotrigine Tablets