Lamotrigine Chewable Dispersible Tablets and Sulfamethoxazole/trimethoprim Intravenous
Determining the interaction of Lamotrigine Chewable Dispersible Tablets and Sulfamethoxazole/trimethoprim Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Lamotrigine is a weak inhibitor of dihydrofolate reductase. Theoretically, coadministration with other dihydrofolate reductase inhibitors may have additive effects on rapidly proliferating tissues such as bone marrow, possibly increasing the risk of megaloblastic anemia and other hematologic adverse effects. However, a clinically significant interaction has not been reported. During prolonged human dosing, lamotrigine did not induce significant changes in the hemoglobin concentration, mean corpuscular volume, or serum or red blood cell folate concentrations for up to one year. No significant effects on red blood cell folate concentration have been observed for up to five years.
- "Product Information. Lamictal (lamotrigine)." Glaxo Wellcome, Research Triangle Park, NC.
Generic Name: lamotrigine
Brand name: Lamictal, Lamictal ODT, Lamictal XR, Subvenite, Lamictal CD, LaMICtal Starter Kit, LaMICtal ODT Patient Titration Kit, LaMICtal XR Patient Titration Kit, LamoTRIgine Starter Kit, Subvenite Starter Kit, Lamictal, Lamictal ODT, Lamictal XR
Synonyms: Lamotrigine, LamoTRIgine
Generic Name: sulfamethoxazole / trimethoprim
Brand name: Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Septra, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS
Synonyms: Sulfamethoxazole/trimethoprim (Intravenous)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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