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Lanoxin (Digoxin Injection) and Reserpine

Determining the interaction of Lanoxin (Digoxin Injection) and Reserpine and the possibility of their joint administration.

Check result:
Lanoxin (Digoxin Injection) <> Reserpine
Relevance: 06.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that rauwolfia alkaloids may increase the risk of arrhythmias when they are given with digoxin. The mechanism is not known. This combination has been commonly used without incident. Data are available for reserpine only. Recommended management consists of decreasing the rauwolfia alkaloid dosage.

References
  • Doggett NS, Case G "Some observations on the interaction between cardiac glycosides and reserpine in the heart and central nervous system." Toxicol Appl Pharmacol 33 (1975): 87-93
Lanoxin (Digoxin Injection)

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

Reserpine

Generic Name: reserpine

Brand name:

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle