Lanoxin (Digoxin Injection) and Samsca

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Tolvaptan may increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with tolvaptan may increase the serum concentrations of digoxin. The proposed mechanism is tolvaptan inhibition of the P-glycoprotein-mediated intestinal or renal efflux of digoxin. According to the tolvaptan product labeling, administration of digoxin in combination with tolvaptan increased digoxin peak concentration (Cmax) by 30% and systemic exposure (AUC) by 20%. Digoxin had no significant effect on the pharmacokinetics of tolvaptan.

MANAGEMENT: Serum digoxin levels and pharmacologic effects should be closely monitored following the addition or withdrawal of tolvaptan, and the digoxin dosage adjusted as needed. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

Lanoxin (Digoxin Injection)

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

What is Lanoxin (Digoxin Injection)?

Samsca

Generic Name: tolvaptan

Brand name: Samsca, Jynarque

Synonyms: n.a.

What is Samsca?