Lanoxin (Digoxin Injection) and Sudafed 12 Hour Pressure + Pain
Determining the interaction of Lanoxin (Digoxin Injection) and Sudafed 12 Hour Pressure + Pain and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking naproxen, tell your doctor if you also use digoxin. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase digoxin levels. You should notify your doctor if you have symptoms of nausea, loss of appetite, visual changes, slow pulse, or irregular heartbeats. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase plasma digoxin concentrations and half-life. The exact mechanism is unknown, but may be related to reduced renal clearance of digoxin. Data have been conflicting. The interaction has been reported with indomethacin and ibuprofen, but data for other NSAIDs are not available.
MANAGEMENT: Patients who require concomitant therapy should be monitored for altered pharmacologic effects of digoxin and for increased plasma levels. The digoxin dosage may require adjustment. Patients should be advised to notify their physician if they experience nausea, anorexia, visual changes, slow pulse, or irregular heartbeats.
- Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
- Finch MB, Johnston GD, Kelly JG, McDevitt DG "Pharmacokinetics of digoxin alone and in the presence of indomethacin therapy." Br J Clin Pharmacol 17 (1984): 353-5
- Marcus FI "Pharmacokinetic interactions between digoxin and other drugs." J Am Coll Cardiol 5 (1985): a82-90
- Brouwers JRBJ, Desmet PAGM "Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs." Clin Pharmacokinet 27 (1994): 462-85
- Jorgensen HS, Christensen HR, Kampmann JP "Interaction between digoxin and indomethacin or ibuprofen." Br J Clin Pharmacol 31 (1991): 108-10
Generic Name: digoxin
Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin
Synonyms: Lanoxin
Generic Name: naproxen / pseudoephedrine
Brand name: Aleve-D Sinus & Cold, Aleve-D Sinus & Headache, Sudafed 12 Hour Pressure + Pain, Aleve Cold and Sinus, Aleve Sinus & Headache, Sudafed PSE, Aleve-D Cold and Sinus, Sudafed Sinus & Pain 12 Hour, Sinus & Cold-D, Sudafed Sinus 12 Hour Pressure + Pain
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lanoxin (Digoxin Injection)-Sudafed 24 Hour
- Lanoxin (Digoxin Injection)-Sudafed Childrens
- Lanoxin (Digoxin Injection)-Sudafed OM Sinus Cold
- Lanoxin (Digoxin Injection)-Sudafed PE
- Lanoxin (Digoxin Injection)-Sudafed PE Cold & Cough
- Lanoxin (Digoxin Injection)-Sudafed PE Cold & Cough Child
- Sudafed 12 Hour Pressure + Pain-Lanoxin (Digoxin Tablets)
- Sudafed 12 Hour Pressure + Pain-Lanoxin Injection Pediatric
- Sudafed 12 Hour Pressure + Pain-Lanoxin Intravenous
- Sudafed 12 Hour Pressure + Pain-Lanoxin Pediatric
- Sudafed 12 Hour Pressure + Pain-Lanoxin Pediatric Intravenous
- Sudafed 12 Hour Pressure + Pain-Lanoxin Tablets