Lanoxin (Digoxin Injection) and Valbenazine Tosylate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Valbenazine may increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with valbenazine may increase serum digoxin concentrations and the risk of digoxin toxicity. The proposed mechanism is decreased clearance due to valbenazine-mediated inhibition of the intestinal P-glycoprotein (P-gp) efflux transport protein.

MANAGEMENT: Caution is advised if valbenazine must be used in combination with digoxin. Pharmacologic response and serum digoxin levels should be monitored more closely whenever valbenazine is added to or withdrawn from therapy, and the digoxin dosage adjusted as necessary. Patients should be advised to notify their physician if they experience potential signs and symptoms of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

Lanoxin (Digoxin Injection)

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

What is Lanoxin (Digoxin Injection)?

Valbenazine Tosylate

Generic Name: valbenazine

Brand name: Ingrezza

Synonyms: Valbenazine

What is Valbenazine Tosylate?