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Lanoxin (Digoxin Tablets) and Paxil CR

Determining the interaction of Lanoxin (Digoxin Tablets) and Paxil CR and the possibility of their joint administration.

Check result:
Lanoxin (Digoxin Tablets) <> Paxil CR
Relevance: 05.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The manufacturer of paroxetine reports that paroxetine may decrease serum digoxin levels by 15%; however, no changes in concentration have also been reported. The mechanism and clinical significance is unknown. If paroxetine and digoxin are used together, monitoring for clinical and laboratory evidence of altered digoxin effect is recommended. Patients should be advised to notify their physician if they experience a worsening of their heart symptoms.

References
  • Bannister SJ, Houser VP, Hulse JD, et al "Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin." Acta Psychiatr Scand 80 (1989): 102-6
  • "Product Information. Paxil (paroxetine)." GlaxoSmithKline, Research Triangle Park, NC.
Lanoxin (Digoxin Tablets)

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

Paxil CR

Generic Name: paroxetine

Brand name: Brisdelle, Paxil, Paxil CR, Pexeva

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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