Lanoxin Pediatric and Micardis

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before taking digoxin, tell your doctor if you also use telmisartan. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase digoxin levels. You should notify your doctor if you have symptoms of nausea, loss of appetite, visual changes, slow pulse, or irregular heartbeats. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

MONITOR: Coadministration with telmisartan may modestly increase the serum concentrations of digoxin. The exact mechanism of interaction is unknown. In twelve healthy volunteers, telmisartan (120 mg orally once a day for 7 days) increased the steady state peak serum concentration (Cmax), area under the concentration-time curve (AUC) and trough concentration (Cmin) of digoxin (0.5 mg orally once, then 0.25 mg once a day for 7 days) by 50%, 22%, and 13%, respectively, compared to administration of digoxin alone. These changes are not thought to be clinically significant, although patients with serum digoxin levels at the upper end of the therapeutic range may be at increased risk for digoxin toxicity. Digoxin did not affect the steady-state pharmacokinetics of telmisartan, and coadministration had no effect on the safety and tolerability of either drug.

MANAGEMENT: Pharmacologic response and serum digoxin levels should be monitored more closely following initiation, discontinuation, or change of dosage of telmisartan in patients who are stabilized on their digoxin regimen. Patients should be advised to contact their physician if they experience signs and symptoms of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

Lanoxin Pediatric

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

What is Lanoxin Pediatric?

Micardis

Generic Name: telmisartan

Brand name: Micardis

Synonyms: n.a.

What is Micardis?