Lanoxin Pediatric Intravenous and Questran Light
Determining the interaction of Lanoxin Pediatric Intravenous and Questran Light and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cholestyramine together with digoxin can decrease the effects of digoxin. You should notify your doctor if you experience worsening of your heart symptoms. Cholestyramine should be administered at least eight hours before or after a digoxin dose. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Cholestyramine may decrease the absorption and possibly the enterohepatic recirculation of digoxin. Digoxin serum concentrations and pharmacologic effect may be reduced.
MANAGEMENT: Cholestyramine should be administered at least eight hours before or after a dose of digoxin. It may be prudent to monitor patients for altered clinical response and to monitor digoxin levels. Patients should be advised to notify their physician if they experience worsening of their heart symptoms. Conversely, patients should be monitored for digoxin toxicity after discontinuation of cholestyramine.
- Brown DD, Juhl RP, Warner SL "Decreased bioavailability of digoxin due to hypocholesterolemic interventions." Circulation 58 (1978): 164-72
- Hall WH, Shappell SD, Doherty JE "Effect of cholestyramine on digoxin absorption and excretion in man." Am J Cardiol 39 (1977): 213-6
- Marcus FI "Pharmacokinetic interactions between digoxin and other drugs." J Am Coll Cardiol 5 (1985): a82-90
- Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
- "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY.
- Rawashdeh NM, al-Hadidi HF, Irshaid YM, Battah AK "Gastrointestinal dialysis of digoxin using cholestyramine." Pharmacol Toxicol 72 (1993): 245-8
Generic Name: digoxin
Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin
Synonyms: Lanoxin
Generic Name: cholestyramine
Brand name: Prevalite, Questran, Questran Light, Cholestyramine Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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