Lanreotide Subcutaneous and Neoral

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Lanreotide may reduce the blood levels and effects of cycloSPORINE. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with somatostatin analogs may decrease the blood concentrations of cyclosporine. The mechanism of interaction is unknown but may involve reduction of intestinal absorption of cyclosporine. In one case report, a patient with kidney and pancreatic segment transplants receiving azathioprine, methylprednisolone, and cyclosporine experienced a presumed episode of transplant rejection in association with reduced cyclosporine levels shortly after initiation of octreotide therapy. His trough cyclosporine levels fell below the limit of detection while serum creatinine increased dramatically. In other cases, significant reductions in cyclosporine levels, sometimes to undetectable levels, have been reported within 24 to 48 hours after octreotide was initiated. No data are available for lanreotide or pasireotide, although a similar interaction is theoretically possible.

MANAGEMENT: Pharmacologic effects and blood concentrations of cyclosporine should be monitored more closely whenever a somatostatin analog is added to or withdrawn from the patient's anti-rejection regimen, and the cyclosporine dosage adjusted as necessary. The investigators of the case report suggest increasing oral cyclosporine dosage on average by 50% prior to initiating octreotide and monitoring cyclosporine blood levels frequently.

Lanreotide Subcutaneous

Generic Name: lanreotide

Brand name: Somatuline Depot

Synonyms: Lanreotide

What is Lanreotide Subcutaneous?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?