Lansoprazole, Amoxicillin, and Clarithromycin and Tolazamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using clarithromycin together with TOLAZamide may increase the effects of TOLAZamide on lowering blood sugar. This could cause your blood sugar levels to get too low. Signs of low blood sugar include headache, hunger, weakness, dizziness, drowsiness, nervousness, sweating, confusion, and tremor. Talk with your doctor before using clarithromycin together with TOLAZamide. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Limited data suggest that clarithromycin may potentiate the hypoglycemic effect of sulfonylureas in susceptible individuals such as the elderly and patients with renal impairment. The exact mechanism is unknown but may involve clarithromycin displacement of sulfonylureas from plasma protein binding sites. The interaction was suspected in two elderly patients (72 and 82 years old) who developed severe hypoglycemia and profound mental status changes within 48 hours after initiating clarithromycin 1000 mg/day for bronchitis. Both patients had type II diabetes that was previously well controlled on diet and sulfonylurea therapy (glipizide 15 mg/day and glyburide 5 mg/day), and both had mild to moderately impaired renal function. The patients were given intravenous glucose with no further incident after discontinuing the sulfonylurea.

MANAGEMENT: Clarithromycin should be prescribed cautiously to diabetic patients with renal impairment who are receiving sulfonylurea therapy, particularly if they are also elderly. Patients should be advised to regularly monitor their blood sugar and counseled on how to recognize and treat hypoglycemia, which may include symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitations. The physician should be notified if an interaction is suspected.

Lansoprazole, Amoxicillin, and Clarithromycin

Generic Name: amoxicillin / clarithromycin / lansoprazole

Brand name: Prevpac

Synonyms: Amoxicillin, clarithromycin, and lansoprazole

What is Lansoprazole, Amoxicillin, and Clarithromycin?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?