Lanthanum carbonate and Tacrolimus Injection
Determining the interaction of Lanthanum carbonate and Tacrolimus Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Lanthanum carbonate and tacrolimus should not be taken orally at the same time. These medications may interfere with each other's absorption into the bloodstream, which may reduce the effects of both medications. To minimize the potential for interaction, avoid taking tacrolimus within 2 hours of taking lanthanum carbonate. Talk to a healthcare professional if you have questions on how to take these or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Theoretically, lanthanum carbonate may chelate with certain drugs in the gastrointestinal tract, resulting in reduced oral bioavailability of those drugs during coadministration. However, an in vitro study involving digoxin, enalapril, furosemide, metoprolol, phenytoin, and warfarin found no evidence that lanthanum carbonate forms insoluble complexes with these drugs in simulated gastric fluid. Studies in healthy subjects have also found no effect of lanthanum carbonate (1000 mg for 4 doses) on the absorption of a single dose of digoxin (0.5 mg), metoprolol (100 mg), or warfarin (10 mg).
MANAGEMENT: To minimize the potential for interaction, drugs that are known to interact with antacids (e.g., ACE inhibitors, beta blockers, bisphosphonates, coumarin derivatives, digitalis glycosides, fluoroquinolones, iron, phenytoin, rifampin, tetracyclines, thyroid preparations, valproic acid) should not be taken within 2 hours of administration of lanthanum carbonate according to the product labeling.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- "Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.
- "Product Information. Fosrenol (lanthanum carbonate)." Shire US Inc, Florence, KY.
- "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc., Boston, MA.
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: lanthanum carbonate
Brand name: Fosrenol
Synonyms: Lanthanum
Generic Name: tacrolimus
Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria
Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lanthanum carbonate-Tacrolimus Intravenous
- Lanthanum carbonate-Tacrolimus oral and injection
- Lanthanum carbonate-Tacrolimus Oral, Intravenous
- Lanthanum carbonate-Tactinal
- Lanthanum carbonate-Tadalafil
- Lanthanum carbonate-Tadalafil Tablets (Cialis)
- Tacrolimus Injection-Lanthanum Carbonate Tablets
- Tacrolimus Injection-Lanthanum Chewable Tablets
- Tacrolimus Injection-Lanthanum Powder
- Tacrolimus Injection-Lantus
- Tacrolimus Injection-Lantus SoloStar
- Tacrolimus Injection-Lantus SoloStar (Insulin Glargine (U-100) Cartridge Systems and Pens)