Lapatinib Ditosylate and Niaspan

• Generic Name: lapatinib
• Dosage Forms: n.a.
• Other Brand Names: Tykerb

In combination with letrozole for treatment of hormone receptor-positive metastatic breast cancer that overexpresses the human epidermal receptor type 2 (HER2) protein in postmenopausal women who are candidates for hormonal therapy. Combined therapy with lapatinib and an aromatase inhibitor has not been compared with trastuzumab-containing chemotherapy for treatment of metastatic breast cancer.

In combination with capecitabine for treatment of advanced or metastatic breast cancer in patients whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and trastuzumab.

• Generic Name: niacin
• Dosage Forms: tablet, film coated, extended release
• Other Brand Names: B-3-50, B3-500-Gr, Niacin SR, Niacor, Niaspan ER, Slo-Niacin

Niaspan ER extended release works by reducing LDL ("bad") cholesterol and triglycerides and increasing HDL ("good") cholesterol. Niaspan contains niacin, also called nicotinic acid, a B vitamin (vitamin B3). It occurs naturally in plants and animals and is present in many multiple vitamin supplements.

Niaspan ER is used to lower cholesterol and triglycerides (types of fat) in the blood. It is also used to lower the risk of heart attack in people with high cholesterol who have already had a heart attack. It is sometimes used to treat coronary artery disease (also called atherosclerosis).

Niaspan ER may also be used for purposes not listed in this medication guide.