Lapatinib Ditosylate and Zantac (Ranitidine Injection)
Determining the interaction of Lapatinib Ditosylate and Zantac (Ranitidine Injection) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using lapatinib together with raNITIdine. In some patients, raNITIdine may interfere with the absorption of lapatinib and reduce its effectiveness. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonclinical data indicate that the solubility of lapatinib is pH-dependent. Therefore, long-term suppression of gastric acid secretion by H2-receptor antagonists or proton pump inhibitors may reduce lapatinib systemic exposure. In study subjects, coadministration with the proton pump inhibitor esomeprazole (40 mg once daily for 7 days) decreased lapatinib exposure by an average of 27% (range 6% to 49%). This effect decreases with increasing age from approximately 40 to 60 years. The clinical significance is unknown.
MANAGEMENT: Caution may be advisable if lapatinib is used in combination with H2-receptor antagonists or proton pump inhibitors. Patients should be monitored for potentially reduced therapeutic response to lapatinib.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Tykerb (lapatinib)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: lapatinib
Brand name: Tykerb
Synonyms: Lapatinib
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Zantac
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lapatinib Ditosylate-Zantac (Ranitidine Syrup)
- Lapatinib Ditosylate-Zantac (Ranitidine Tablets and Capsules)
- Lapatinib Ditosylate-Zantac Cool Mint
- Lapatinib Ditosylate-Zantac Injection
- Lapatinib Ditosylate-Zapzyt Cleansing Topical
- Lapatinib Ditosylate-Zapzyt Topical
- Zantac (Ranitidine Injection)-Lariam
- Zantac (Ranitidine Injection)-Larin 1.5/30
- Zantac (Ranitidine Injection)-Larin 1/20
- Zantac (Ranitidine Injection)-Larin 24 Fe
- Zantac (Ranitidine Injection)-Larin Fe 1.5/30
- Zantac (Ranitidine Injection)-Larin Fe 1/20