Lariam and Norvir Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

The coadministration with mefloquine may decrease the steady-state, but not single-dose, plasma concentrations of ritonavir. The mechanism is unknown but may be due to reduction of bile production by mefloquine, which may interfere with the solubility and absorption of ritonavir in the small intestine. In a study consisting of 12 healthy volunteers, mefloquine (250 mg orally once daily for 3 days, then once weekly for 4 weeks) decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of ritonavir (200 mg orally twice daily for 7 days) by 36% and 31%, respectively. The clearance increased by an average of 45% with no change in half-life or plasma protein binding. However, not all subjects had decreased ritonavir concentrations. Also, in a separate phase of the study involving 11 volunteers (8 of whom participated in the first phase), single-dose pharmacokinetics of ritonavir were not altered by mefloquine. Thus, the effects of the interaction, if it exists, may be inconsistent and subject to interpatient variability. Ritonavir had minimal effect on the pharmacokinetics of mefloquine and its carboxylic acid metabolite, despite strong inhibition of CYP450 3A4 activity as demonstated by the erythromycin breath test. Further studies are necessary to confirm or disprove the interaction.

Lariam

Generic Name: mefloquine

Brand name: Lariam

Synonyms: n.a.

What is Lariam?

Norvir Tablets

Generic Name: ritonavir

Brand name: Norvir, Norvir Soft Gelatin

Synonyms: Ritonavir

What is Norvir Tablets?