Larotrectinib and Rolapitant Intravenous
Determining the interaction of Larotrectinib and Rolapitant Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with rolapitant may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter. When a 0.5 mg dose of digoxin, a P-gp probe substrate, was administered with a 180 mg dose of rolapitant, digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 70% and 30%, respectively. MANAGEMENT: Caution is advised when rolapitant is prescribed with drugs that are P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever rolapitant is added to or withdrawn from therapy. References "Product Information. Varubi (rolapitant)." Tesaro Inc., Waltham, MA.
Professional:MONITOR: Coadministration with rolapitant may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter. When a 0.5 mg dose of digoxin, a P-gp probe substrate, was administered with a 180 mg dose of rolapitant, digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 70% and 30%, respectively.
MANAGEMENT: Caution is advised when rolapitant is prescribed with drugs that are P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever rolapitant is added to or withdrawn from therapy.
- "Product Information. Varubi (rolapitant)." Tesaro Inc., Waltham, MA.
Generic Name: larotrectinib
Brand name: Vitrakvi
Synonyms: n.a.
Generic Name: rolapitant
Brand name: Varubi
Synonyms: Rolapitant
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Larotrectinib-Rolapitant Tablets
- Larotrectinib-Romazicon
- Larotrectinib-Romidepsin
- Larotrectinib-Romidepsin Injection
- Larotrectinib-Romidepsin Intravenous
- Larotrectinib-Romiplostim
- Rolapitant Intravenous-Larotrectinib Capsules
- Rolapitant Intravenous-Larotrectinib Oral Solution
- Rolapitant Intravenous-Larotrectinib Sulfate
- Rolapitant Intravenous-Lartruvo
- Rolapitant Intravenous-Larynex
- Rolapitant Intravenous-Laryng-O-Jet