Larotrectinib and Sarecycline
Determining the interaction of Larotrectinib and Sarecycline and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with sarecycline may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, kidney, and/or liver due to inhibition of P-gp-mediated efflux by sarecycline. When the probe P-gp substrate digoxin was coadministered with a single 150 mg dose of sarecycline, digoxin peak plasma concentration (Cmax) increased by 26%. MANAGEMENT: Caution is advised when sarecycline is used concurrently with drugs that are P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever sarecycline is added to or withdrawn from therapy. References "Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.
Professional:MONITOR: Coadministration with sarecycline may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, kidney, and/or liver due to inhibition of P-gp-mediated efflux by sarecycline. When the probe P-gp substrate digoxin was coadministered with a single 150 mg dose of sarecycline, digoxin peak plasma concentration (Cmax) increased by 26%.
MANAGEMENT: Caution is advised when sarecycline is used concurrently with drugs that are P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever sarecycline is added to or withdrawn from therapy.
- "Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.
Generic Name: larotrectinib
Brand name: Vitrakvi
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Larotrectinib-Sarecycline Hydrochloride
- Larotrectinib-Sargramostim
- Larotrectinib-Sargramostim Intravenous
- Larotrectinib-Sargramostim Powder for Injection
- Larotrectinib-Sargramostim Solution for Injection
- Larotrectinib-Sarilumab
- Sarecycline-Larotrectinib Capsules
- Sarecycline-Larotrectinib Oral Solution
- Sarecycline-Larotrectinib Sulfate
- Sarecycline-Lartruvo
- Sarecycline-Larynex
- Sarecycline-Laryng-O-Jet