Larotrectinib Sulfate and Sertraline Oral Liquid

• Generic Name: larotrectinib
• Dosage Forms: n.a.
• Other Brand Names: Vitrakvi

Treatment of solid tumors harboring an NTRK fusion (without a known acquired mutation for resistance) in patients who have metastatic disease or may experience severe morbidity following surgical resection and whose disease progressed following prior therapy or those who are not candidates for other treatment options (designated an orphan drug by FDA for these cancers).

Accelerated approval based on overall response rate and duration of response. Continued approval may be contingent on verification and description of clinical benefit in confirmatory studies.

Confirmation of the presence of NTRK fusion is necessary prior to initiation of therapy. In clinical studies, NTRK fusion status of tumor specimens was determined by fluorescence in situ hybridization (FISH), reverse transcription-polymerase chain reaction (RT-PCR), or next-generation sequencing (NGS).

• Generic Name: sertraline
• Dosage Forms: n.a.
• Other Brand Names: Zoloft

• It is used to treat low mood (depression).
• It is used to treat obsessive-compulsive problems.
• It is used to treat panic attacks.
• It is used to treat post-traumatic stress.
• It is used to treat mood problems caused by monthly periods.
• It is used to treat social anxiety problems.
• It may be given to you for other reasons. Talk with the doctor.