Lasmiditan and Physostigmine Ophthalmic
Determining the interaction of Lasmiditan and Physostigmine Ophthalmic and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration of lasmiditan and agents that lower heart rate may increase the risk of bradycardia. In clinical trials, lasmiditan was associated with heart rate decreases of 5 to 10 beats per minute (bpm) while placebo was associated with decreases of 2 to 5 bpm. In a drug interaction study, a single 200 mg dose of lasmiditan led to an additional heart rate decrease of 5 bpm when given with propranolol. MANAGEMENT: Caution is advised during coadministration of lasmiditan and agents that lower heart rate if the estimated decrease in heart rate may present a clinical risk. Consider monitoring heart rate in patients for whom the estimated decrease in heart rate may not be tolerated. References "Product Information. Reyvow (lasmiditan)." Lilly, Eli and Company, Indianapolis, IN.
Professional:MONITOR: Coadministration of lasmiditan and agents that lower heart rate may increase the risk of bradycardia. In clinical trials, lasmiditan was associated with heart rate decreases of 5 to 10 beats per minute (bpm) while placebo was associated with decreases of 2 to 5 bpm. In a drug interaction study, a single 200 mg dose of lasmiditan led to an additional heart rate decrease of 5 bpm when given with propranolol.
MANAGEMENT: Caution is advised during coadministration of lasmiditan and agents that lower heart rate if the estimated decrease in heart rate may present a clinical risk. Consider monitoring heart rate in patients for whom the estimated decrease in heart rate may not be tolerated.
- "Product Information. Reyvow (lasmiditan)." Lilly, Eli and Company, Indianapolis, IN.
Generic Name: physostigmine ophthalmic
Brand name:
Synonyms: Physostigmine (Ophthalmic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lasmiditan-Physostigmine Salicylate
- Lasmiditan-Phytonadione
- Lasmiditan-Phytonadione Injection
- Lasmiditan-Phytonadione oral/injection
- Lasmiditan-Phytonadione Orally Disintegrating Tablets
- Lasmiditan-Phytonadione Tablets
- Physostigmine Ophthalmic-Latanoprost
- Physostigmine Ophthalmic-Latanoprost and netarsudil ophthalmic
- Physostigmine Ophthalmic-Latanoprost and Timolol
- Physostigmine Ophthalmic-Latanoprost Eye Drops (Emulsion)
- Physostigmine Ophthalmic-Latanoprost Eye Drops (Solution)
- Physostigmine Ophthalmic-Latanoprost ophthalmic