Leader Acid Control and Metformin and sitagliptin
Determining the interaction of Leader Acid Control and Metformin and sitagliptin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using metFORMIN together with raNITIdine may increase the effects of metFORMIN, which may lead to a life-threatening condition called lactic acidosis This can cause weakness, increasing sleepiness, slow heart rate, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting. Talk with your doctor before using metFORMIN while you are using raNITIdine. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Ranitidine is a cationic drug and theoretically could decrease the excretion of metformin by competing for renal tubular transport. Although this interaction has not been specifically reported for ranitidine, cimetidine (also a cationic drug) has been reported to interact with metformin in this manner. Increased metformin levels may increase the risk of lactic acidosis.
MANAGEMENT: If ranitidine and metformin must be used together, particularly slow and cautious titration of metformin dosage is recommended. The maximal dose of metformin probably also should be reduced until further information about this interaction is available. Patients should be advised to monitor their blood glucose and to promptly notify their physician if they experience possible signs of lactic acidosis such as malaise, myalgia, respiratory distress, hyperventilation, slow or irregular heartbeat, somnolence, abdominal upset, or other unusual symptoms.
- "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.
- Somogyi A, Stockley C, Keal J, Rolan P, Bochner F "Reduction of metformin renal tubular secretion by cimetidine in man." Br J Clin Pharmacol 23 (1987): 545-51
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Ranitidine
Generic Name: metformin / sitagliptin
Brand name: Janumet, Janumet XR
Synonyms: Sitagliptin and Metformin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Leader Acid Control-Metformin Extended-Release Tablets
- Leader Acid Control-Metformin Hydrochloride
- Leader Acid Control-Metformin Oral Solution
- Leader Acid Control-Metformin Tablets
- Leader Acid Control-Methacholine
- Leader Acid Control-Methadone
- Metformin and sitagliptin-Leader Acid Reducer Maximum Strength
- Metformin and sitagliptin-Leader All Day Allergy
- Metformin and sitagliptin-Leader Allergy D 12
- Metformin and sitagliptin-Leader Allergy Relief
- Metformin and sitagliptin-Leader Allergy Relief D-24
- Metformin and sitagliptin-Leader Allerhist