Ledipasvir and sofosbuvir and Sodium Bicarbonate Infant Injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Antacids may interfere with the absorption of ledipasvir and reduce its effectiveness. Products with antacid effects typically contain aluminum hydroxide, calcium carbonate, magnesium hydroxide, magnesium carbonate, magnesium oxide, magaldrate, sodium bicarbonate, and/or sodium citrate. To prevent or minimize the interaction, antacid-containing preparations should be taken 4 hours before or 4 hours after the ledipasvir dose. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Concurrent administration of ledipasvir with drugs that elevate gastric pH such as antacids may reduce its gastrointestinal absorption. Ledipasvir exhibits pH-dependent solubility, with increased solubility at lower pH. Drugs that increase gastric pH are expected to decrease the plasma concentration of ledipasvir.

MANAGEMENT: If an antacid is required, the antacid should be taken 4 hours before or 4 hours after administration of ledipasvir-sofosbuvir. The same precaution may be applicable to other drugs with antacid effects.

Ledipasvir and sofosbuvir

Generic Name: ledipasvir / sofosbuvir

Brand name: Harvoni

Synonyms: Ledipasvir and Sofosbuvir

What is Ledipasvir and sofosbuvir?

Sodium Bicarbonate Infant Injection

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Sodium bicarbonate, Sodium Bicarbonate

What is Sodium Bicarbonate Infant Injection?