Ledipasvir and Sofosbuvir Tablets and Omeprazole Delayed-Release Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Depending on the dose, omeprazole may interfere with the absorption of ledipasvir and reduce its effectiveness. Talk to your doctor or pharmacist if you have any questions or concerns. You may need a dose adjustment of omeprazole to safely use both medications. You should take omeprazole simultaneously with the dose of ledipasvir on an empty stomach. Contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration of ledipasvir with proton pump inhibitors may reduce its gastrointestinal absorption. Ledipasvir exhibits pH-dependent solubility, with increased solubility at lower pH. In 17 healthy volunteers, mean ledipasvir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 48% and 42%, respectively, when a single 30 mg dose of ledipasvir was administered 2 hours after omeprazole given at a dosage of 20 mg once daily. When a single 90 mg-400 mg dose of ledipasvir-sofosbuvir was administered simultaneously with omeprazole 20 mg once daily, mean ledipasvir Cmax decreased by 11% and AUC decreased by just 4%.

MANAGEMENT: Proton-pump inhibitors at doses comparable to omeprazole 20 mg or lower should only be administered either simultaneously with or up to 2 hours after ledipasvir-sofosbuvir under fasted conditions. Some authorities advise against administering proton pump inhibitors before ledipasvir-containing products; however, a timeframe of dosage separation has not been specified.

Ledipasvir and Sofosbuvir Tablets

Generic Name: ledipasvir / sofosbuvir

Brand name: Harvoni

Synonyms: Ledipasvir and sofosbuvir, Ledipasvir and Sofosbuvir

What is Ledipasvir and Sofosbuvir Tablets?

Omeprazole Delayed-Release Capsules

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Zegerid>, Prilosec, Prilosec OTC

Synonyms: Omeprazole

What is Omeprazole Delayed-Release Capsules?