Ledipasvir and Sofosbuvir Tablets and Posaconazole Intravenous
Determining the interaction of Ledipasvir and Sofosbuvir Tablets and Posaconazole Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ledipasvir may increase the blood levels and effects of posaconazole. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with ledipasvir may increase the plasma concentrations of orally administered drugs that are substrates of the P-glycoprotein (P-gp) and/or breast cancer resistance protein (BCRP) transporters. The proposed mechanism is decreased clearance in the intestine due to inhibition of P-gp or BCRP-mediated drug efflux by ledipasvir.
MANAGEMENT: Caution is advised if ledipasvir must be used concurrently with medications that are substrates of the P-gp and/or BCRP transporters, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever ledipasvir is added to or withdrawn from therapy.
- "Product Information. Harvoni (ledipasvir-sofosbuvir)." Gilead Sciences, Foster City, CA.
Generic Name: ledipasvir / sofosbuvir
Brand name: Harvoni
Synonyms: Ledipasvir and sofosbuvir, Ledipasvir and Sofosbuvir
Generic Name: posaconazole
Brand name: Noxafil
Synonyms: Posaconazole (oral/injection), Posaconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ledipasvir and Sofosbuvir Tablets-Posaconazole Oral Suspension
- Ledipasvir and Sofosbuvir Tablets-Posaconazole oral/injection
- Ledipasvir and Sofosbuvir Tablets-Posaconazole Tablets
- Ledipasvir and Sofosbuvir Tablets-PosiFlush flush
- Ledipasvir and Sofosbuvir Tablets-Positive Skin Test Control - Histamine
- Ledipasvir and Sofosbuvir Tablets-Posture
- Posaconazole Intravenous-Leena
- Posaconazole Intravenous-Lefamulin
- Posaconazole Intravenous-Lefamulin Acetate
- Posaconazole Intravenous-Lefamulin Injection
- Posaconazole Intravenous-Lefamulin Tablets
- Posaconazole Intravenous-Leflunomide