Leflunomide and Questran Light
Determining the interaction of Leflunomide and Questran Light and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using cholestyramine together with leflunomide. Using these medications together can make leflunomide less effective. Do not take cholestyramine with any other medication. Cholestyramine binds to other drugs and reduces their effectiveness, which could become dangerous. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: A significant decrease in M1, the active metabolite of leflunomide, has resulted when cholestyramine or activated charcoal is administered to patients receiving leflunomide. Administration of cholestyramine 8 grams 3 times a day has resulted in a 40% decrease in plasma levels of M1 in a 24 hour period.
MANAGEMENT: Coadministration of these drugs is not recommended.
- "Product Information. Arava (leflunomide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Generic Name: cholestyramine
Brand name: Prevalite, Questran, Questran Light, Cholestyramine Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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