Leflunomide and Teriflunomide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using leflunomide together with teriflunomide is not recommended. Combining these medications may increase the risk of serious side effects such as nerve damage, liver injury, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Consult with your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Teriflunomide is the active metabolite of leflunomide and has a similar toxicity profile as the parent drug.

MANAGEMENT: Concomitant use of leflunomide and teriflunomide is considered contraindicated due to the potential for increased toxicities such as peripheral neuropathy, serious liver injury, and bone marrow suppression.

Leflunomide

Generic Name: leflunomide

Brand name: Arava

Synonyms: n.a.

What is Leflunomide?

Teriflunomide

Generic Name: teriflunomide

Brand name: Aubagio

Synonyms: n.a.

What is Teriflunomide?