Leflunomide and Tolazamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Leflunomide may increase the blood levels and effects of TOLAZamide. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The active metabolite of leflunomide, known as A771726 or M1, has been shown to inhibit CYP450 2C9 in vitro and may increase the plasma concentrations of drugs that are substrates of the isoenzyme, including many nonsteroidal anti-inflammatory drugs (NSAIDs), sulfonylureas, phenytoin, and warfarin. According to leflunomide labeling, M1 caused increases ranging from 13% to 50% in the free fraction of diclofenac, ibuprofen, and tolbutamide at concentrations in the clinical range. M1 has also been shown in vitro to inhibit the formation of 4-hydroxydiclofenac from diclofenac. The clinical significance of these findings is unknown. There was extensive concomitant use of NSAIDs in clinical studies of leflunomide, and no differential effect was observed.

MANAGEMENT: Caution is advised if leflunomide is coadministered with drugs that are metabolized by CYP450 2C9, such as phenytoin, warfarin, and sulfonylureas. Clinical and laboratory monitoring may be appropriate whenever leflunomide is added to or withdrawn from therapy, and the dosages adjusted as necessary.

Leflunomide

Generic Name: leflunomide

Brand name: Arava

Synonyms: n.a.

What is Leflunomide?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?