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Lemtrada and Zostavax

Determining the interaction of Lemtrada and Zostavax and the possibility of their joint administration.

Check result:

Lemtrada <> Zostavax

Relevance: 13.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

If you are currently being treated or have recently been treated with alemtuzumab, you should talk to your doctor before receiving zoster vaccine live. Depending on the dose and length of time you have been on alemtuzumab, you may be at risk for developing an infection from the vaccine or have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of alemtuzumab therapy. If you have recently been vaccinated with zoster vaccine live, your doctor may choose to postpone treatment with alemtuzumab for a couple of weeks. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: The administration of live, attenuated virus or bacterial vaccines during immunosuppressant or intense antineoplastic therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. Patients may be immunosuppressed if they have recently received or are receiving alkylating agents, antimetabolites, radiation, some antirheumatic agents, high dosages of corticosteroids or adrenocorticotropic agents, or long-term topical or inhaled corticosteroids. These patients may also have increased adverse reactions and decreased or suboptimal immunologic response to vaccines.

MANAGEMENT: In general, live virus or bacterial vaccines should not be used in patients receiving immunosuppressive therapy or cancer chemotherapy. Vaccination should be deferred until after such therapy is discontinued for at least 3 months in most cases. In patients who have recently been vaccinated, such therapy should not be initiated for at least 2 weeks.

References

Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):
CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18
"Product Information. Campath (alemtuzumab)" Berlex, Richmond, CA.

Lemtrada

Generic Name: alemtuzumab

Brand name: Campath, Lemtrada

Synonyms: n.a.

What is Lemtrada?

Zostavax

Generic Name: zoster vaccine live

Brand name: Zostavax

Synonyms: n.a.

What is Zostavax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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