Lesinurad and Allopurinol and Thalitone
Determining the interaction of Lesinurad and Allopurinol and Thalitone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking allopurinol, tell your doctor if you also use chlorthalidone. You may need dose adjustments to safely take both medications together. You should notify your doctor if you have symptoms of a rash, itching, fever, or chills. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Serious hypersensitivity reactions to allopurinol have been well-documented in the medical literature. Case reports have suggested that thiazide diuretics may increase the risk of allopurinol-induced hypersensitivity reactions, especially in patients with renal insufficiency. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite).
MANAGEMENT: Patients should be advised to promptly report any signs of hypersensitivity, including rash, pruritus, fever, or chills.
- Hande KR "Evaluation of a thiazide-allopurinol drug interaction." Am J Med Sci 292 (1986): 213-6
- Devries JX, Voss A, Ittensohn A, Waltersack I, Loffler W, Landthaler R, Zollner N "Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects. 2. kinetics of allopurinol, oxipurinol, and hydrochlorothiazide." Clin Investig 72 (1994): 1076-81
- Mills RM "Severe hypersensitivity reactions associated with allopurinol." JAMA 216 (1971): 799-802
- Maschio G, Tessitore N, D'Angelo A, Fabris A, Pagano F, Tasca A, Graziani G, Aroldi A, Surian M, Colussi G, Mandressi A, Trinchieri ARocco F, Ponticel "Prevention of calcium nephrolithiasis with low-dose thiazide, amiloride and allopurinol." Am J Med 71 (1981): 623-6
- Loffler W, Landthaler R, Devries JX, Waltersack I, Ittensohn A, Voss A, Zollner N "Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects." Clin Investig 72 (1994): 1071-5
Generic Name: allopurinol / lesinurad
Brand name: Duzallo
Synonyms: Allopurinol and lesinurad
Generic Name: chlorthalidone
Brand name: Hygroton, Thalitone
Synonyms: Thalitone (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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