Letermovir Injection and Treprostinil inhalation

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Letermovir may increase the blood levels of treprostinil. Let your doctor know if you experience increased side effects of treprostinil such as dizziness, lightheadedness, fainting, flushing, diarrhea, unusual bleeding or bruising, and swelling of the arms or legs. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 2C8 may increase the plasma concentrations of treprostinil, which is primarily metabolized by the isoenzyme. Human pharmacokinetic studies with an oral formulation of treprostinil indicate that concomitant administration of the CYP450 2C8 inhibitor gemfibrozil increases exposure (both Cmax and AUC) to treprostinil. However, it has not been determined if the safety and efficacy of treprostinil administered subcutaneously or intravenously are altered by this interaction.

MANAGEMENT: Pharmacologic response to treprostinil should be monitored more closely whenever a CYP450 2C8 inhibitor is added to or withdrawn from therapy, and the treprostinil dosage adjusted as necessary. Patients should be advised to notify their physician if they experience excessive adverse effects of treprostinil such as dizziness, lightheadedness, flushing, diarrhea, edema, and unusual bleeding or bruising.

Letermovir Injection

Generic Name: letermovir

Brand name: Prevymis

Synonyms: Letermovir (oral/injection), Letermovir

What is Letermovir Injection?

Treprostinil inhalation

Generic Name: treprostinil

Brand name: Orenitram, Remodulin, Tyvaso, Tyvaso Refill Kit, Tyvaso Starter Kit

Synonyms: Treprostinil

What is Treprostinil inhalation?