Leucovorin injection and Panobinostat Lactate

• Generic Name: leucovorin
• Dosage Forms: n.a.
• Other Brand Names: Wellcovorin

Leucovorin is a form of folic acid (a type of vitamin B). Folic acid helps your body produce and maintain new cells, and also helps prevent changes in DNA that may lead to cancer. A lack of folic acid in the body can cause anemia, a decrease in red blood cells that carry oxygen through your blood to your tissues and organs.

Leucovorin is used to treat anemia (low red blood cells) caused by a lack of natural folic acid in the body.

Leucovorin is also used to prevent serious side effects caused by large doses or accidental overdose of medications that can reduce the effects of folic acid in the body. This includes methotrexate, pyrimethamine, and others.

Leucovorin is sometimes used in a chemotherapy combination to lengthen survival time in people with advanced colorectal cancer. Leucovorin does not treat the cancer itself.

Leucovorin may also be used for purposes not listed in this medication guide.

• Generic Name: panobinostat
• Dosage Forms: n.a.
• Other Brand Names: Farydak

In combination with bortezomib and dexamethasone for treatment of multiple myeloma in patients who have received ≥2 prior therapies, including bortezomib and an immunomodulatory agent (designated an orphan drug by FDA for use in this condition ).

Accelerated approval based on progression-free survival; continued approval may be contingent on verification and description of clinical benefit in confirmatory studies.