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Leustatin injection and Phenytoin Sodium

Determining the interaction of Leustatin injection and Phenytoin Sodium and the possibility of their joint administration.

Check result:

Leustatin injection <> Phenytoin Sodium

Relevance: 20.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.MONITOR: Cladribine exposure may be decreased by potent inducers of breast cancer resistance protein (BCRP) or P-glycoprotein (P-gp). The mechanism involves induction of BCRP and/or P-gp as cladribine is a substrate of each of these transporter systems. The clinical relevance remains unknown. MANAGEMENT: Possible decreases in cladribine exposure and efficacy should be considered if potent inducers of BCRP or P-gp are coadministered. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ. Cerner Multum, Inc. "Australian Product Information." O 0

Professional:

MONITOR: Cladribine exposure may be decreased by potent inducers of breast cancer resistance protein (BCRP) or P-glycoprotein (P-gp). The mechanism involves induction of BCRP and/or P-gp as cladribine is a substrate of each of these transporter systems. The clinical relevance remains unknown.

MANAGEMENT: Possible decreases in cladribine exposure and efficacy should be considered if potent inducers of BCRP or P-gp are coadministered.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0

Leustatin injection

Generic Name: cladribine

Brand name: Leustatin, Mavenclad

Synonyms: Leustatin (injection), Leustatin

What is Leustatin injection?

Phenytoin Sodium

Generic Name: phenytoin

Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytoin Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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