Leustatin injection and Rifampin Oral, Intravenous
Determining the interaction of Leustatin injection and Rifampin Oral, Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Cladribine exposure may be decreased by potent inducers of breast cancer resistance protein (BCRP) or P-glycoprotein (P-gp). The mechanism involves induction of BCRP and/or P-gp as cladribine is a substrate of each of these transporter systems. The clinical relevance remains unknown. MANAGEMENT: Possible decreases in cladribine exposure and efficacy should be considered if potent inducers of BCRP or P-gp are coadministered. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ. Cerner Multum, Inc. "Australian Product Information." O 0
Professional:MONITOR: Cladribine exposure may be decreased by potent inducers of breast cancer resistance protein (BCRP) or P-glycoprotein (P-gp). The mechanism involves induction of BCRP and/or P-gp as cladribine is a substrate of each of these transporter systems. The clinical relevance remains unknown.
MANAGEMENT: Possible decreases in cladribine exposure and efficacy should be considered if potent inducers of BCRP or P-gp are coadministered.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ.
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: cladribine
Brand name: Leustatin, Mavenclad
Synonyms: Leustatin (injection), Leustatin
Generic Name: rifampin
Brand name: Rifadin, Rifadin IV, Rimactane
Synonyms: Rifampin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Leustatin injection-Rifampin, Isoniazid, and Pyrazinamide
- Leustatin injection-Rifamycin
- Leustatin injection-Rifamycin Sodium
- Leustatin injection-Rifapentine
- Leustatin injection-Rifater
- Leustatin injection-Rifaximin
- Rifampin Oral, Intravenous-Leva Set
- Rifampin Oral, Intravenous-Levacet
- Rifampin Oral, Intravenous-Levalbuterol
- Rifampin Oral, Intravenous-Levalbuterol HFA Aerosol
- Rifampin Oral, Intravenous-Levalbuterol inhalation
- Rifampin Oral, Intravenous-Levalbuterol Inhalation Aerosol