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Levalbuterol Inhalation Solution Concentrate and Silenor

Determining the interaction of Levalbuterol Inhalation Solution Concentrate and Silenor and the possibility of their joint administration.

Check result:

Levalbuterol Inhalation Solution Concentrate <> Silenor

Relevance: 24.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using doxepin together with levalbuterol may increase cardiovascular side effects such as heart palpitations, chest pain, irregular heartbeat, increased heart and pulse rates, and blood pressure elevations. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. The risk exists even when levalbuterol or similar medications are given by oral inhalation directly into the lungs, and more so if these products are overused. Do not exceed the dose and frequency of use recommended on the product label or prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant use of beta-2 adrenergic agonists with tricyclic antidepressants (TCAs) may increase the risk and/or severity of cardiovascular adverse effects such as hypertension, palpitation, chest pain, and arrhythmia. In addition, both classes of drugs have been reported to produce electrocardiographic changes including flattening of the T wave and prolongation of the QTc interval, and these effects may be additive during coadministration.

MANAGEMENT: Caution is advised if beta-2 agonists are used with TCAs, or within two weeks of discontinuing the latter. Cardiovascular status should be closely monitored.

References

"Product Information. Arcapta Neohaler (indacaterol)." Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Alupent (metaproterenol)." Boehringer-Ingelheim, Ridgefield, CT.
"Product Information. Maxair (pirbuterol)." 3M Pharmaceuticals, St. Paul, MN.
"Product Information. Severent (salmeterol)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Striverdi Respimat (olodaterol)." Boehringer Ingelheim, Ridgefield, CT.
"Product Information. Tornalate Metered Dose (bitolterol)." Dura Pharmaceuticals, San Diego, CA.
"Product Information. Foradil (formoterol)" Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Proventil (albuterol)." Schering Laboratories, Kenilworth, NJ.
"Product Information. Breo Ellipta (fluticasone-vilanterol)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Xopenex (levalbuterol)." Sepracor, Marlborough, MA.
"Product Information. Brovana (arformoterol)." Sepracor Inc, Marlborough, MA.

Levalbuterol Inhalation Solution Concentrate

Generic Name: levalbuterol

Brand name: Xopenex, Xopenex Concentrate, Xopenex HFA

Synonyms: Levalbuterol inhalation, Levalbuterol

What is Levalbuterol Inhalation Solution Concentrate?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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