Levobunolol and Pilopine-HS
Determining the interaction of Levobunolol and Pilopine-HS and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data indicate that addition of pilocarpine to levobunolol eye drops significantly decreases ocular absorption of levobunolol. The ocular absorption of levobunolol is pH-dependent, and pilocarpine significantly buffers levobunolol ophthalmic solutions. At acidic pH, the ocular absorption of levobunolol in the presence of pilocarpine may be enhanced by the use of sulfosuccinates.
- Tangliu DD, Richman JB "The effect of pilocarpine on ocular levobunolol absorption from ophthalmic solutions." J Ocul Pharmacol 10 (1994): 605-15
Generic Name: levobunolol ophthalmic
Brand name: Betagan, Akbeta, Levobunolol, Betagan C-Cap
Synonyms: Levobunolol ophthalmic
Generic Name: pilocarpine ophthalmic
Brand name: Pilocar, Pilopine-HS, Pilostat, Isopto Carpine, Adsorbocarpine, Pilagan with C Cap, Ocu-Carpine, Ocusert, Piloptic-1/2, Piloptic-1, Akarpine, Piloptic-2, Piloptic-3, Piloptic-4, Piloptic-6
Synonyms: Pilopine HS
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Levobunolol-Pilostat
- Levobunolol-Pima
- Levobunolol-Pimavanserin
- Levobunolol-Pimavanserin Capsules
- Levobunolol-Pimavanserin Tablets
- Levobunolol-Pimavanserin Tartrate
- Pilopine-HS-Levobunolol Hydrochloride
- Pilopine-HS-Levobunolol ophthalmic
- Pilopine-HS-Levocarnitine
- Pilopine-HS-Levocarnitine Capsules and Tablets
- Pilopine-HS-Levocarnitine Injection
- Pilopine-HS-Levocarnitine Injection Solution