Levocarnitine Injection and Tesamorelin Acetate

• Generic Name: levocarnitine
• Dosage Forms: injection, solution
• Other Brand Names: Carnitor, L-Carnitine, Carnitor SF

Orally for treatment of primary systemic carnitine deficiency, in addition to supportive and other therapy as indicated by the patient’s condition; designated an orphan drug by FDA for this use.

Orally and parenterally for acute or chronic treatment in patients with secondary carnitine deficiency resulting from an inborn error of metabolism; designated an orphan drug by FDA for this use.

Parenterally for prevention and treatment of carnitine deficiency in patients with end-stage renal disease undergoing dialysis (dialysis-related carnitine disorder); designated an orphan drug by FDA for this use.

Effects of supplemental carnitine on manifestations of carnitine deficiency and on clinical outcomes in patients with end-stage renal disease undergoing dialysis not determined.

• Generic Name: tesamorelin
• Dosage Forms: n.a.
• Other Brand Names: Egrifta

Reduction of excess abdominal fat in patients with HIV-associated lipodystrophy. Selectively reduces visceral adipose tissue, preserves subcutaneous fat, and improves body image.

Long-term cardiovascular benefits and safety not known; carefully consider whether to continue the drug in patients who fail to achieve a substantial clinical response (based on degree of visceral adipose tissue reduction as measured by waist circumference or computed tomography [CT] scan).

Not indicated for weight loss management.

Insufficient evidence to support improved compliance with antiretroviral therapies in HIV-infected patients.