Levodopa inhalation and Theraflu Warming Relief Nighttime Severe Cold

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using diphenhydrAMINE together with levodopa may decrease the effects of levodopa. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Anticholinergic agents may decrease the absorption and oral bioavailability of levodopa. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents, thereby increasing the gastric degradation of levodopa and reducing the amount available for absorption in the small intestine. In one study, pretreatment with trihexyphenidyl decreased the peak plasma concentration (Cmax) and delayed the time to peak concentration (Tmax) of levodopa in 3 of 6 healthy volunteers and 4 of 6 Parkinson patients. In another study, 42% of patients receiving levodopa with anticholinergic therapy developed abnormal involuntary movements compared to 19% of those treated with levodopa alone. Discontinuation or dosage reduction of anticholinergic therapy resulted in disappearance or amelioration of the symptoms in 9 of 10 cases, although subsequent aggravation of Parkinsonism necessitated resumption of anticholinergic therapy in 5 cases. There is also a case report describing a patient who required large doses of levodopa during concomitant therapy with homatropine. Following discontinuation of homatropine, the patient exhibited symptoms of levodopa toxicity and required a significant decrease in the levodopa dosage. Other studies have reported no effect of anticholinergic agents on levodopa blood levels or pharmacologic effects.

MANAGEMENT: Although certain anticholinergic agents may be used as adjunctive therapy in Parkinson's disease, clinicians should recognize their potential to reduce the oral bioavailability of levodopa in some patients. Pharmacologic response to levodopa should be monitored more closely whenever anticholinergic agents are added to or withdrawn from therapy, and the dosages of the drugs adjusted as necessary.

Levodopa inhalation

Generic Name: levodopa

Brand name: Inbrija, Dopar, Larodopa

Synonyms: Levodopa (Oral Inhalation)

What is Levodopa inhalation?

Theraflu Warming Relief Nighttime Severe Cold

Generic Name: acetaminophen / diphenhydramine / phenylephrine

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Synonyms: n.a.

What is Theraflu Warming Relief Nighttime Severe Cold?