Levofloxacin (Systemic) and Paclitaxel Concentrate Injection
Determining the interaction of Levofloxacin (Systemic) and Paclitaxel Concentrate Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that chemotherapy with antineoplastic agents may reduce the plasma concentrations of oral quinolone antibiotics. The proposed mechanism is decreased quinolone absorption secondary to alteration of intestinal mucosa by cancer chemotherapy. In six patients with newly diagnosed hematologic malignancy, treatment with various antineoplastic agents (cyclophosphamide, cytarabine, daunorubicin, doxorubicin, mitoxantrone, prednisolone, vincristine) decreased the mean peak serum concentration (Cmax) and area under the concentration-time curve (AUC 0 to 4 hours) of ciprofloxacin by approximately 46% each. Data are not available for other quinolone antibiotics.
- Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42
Generic Name: levofloxacin
Brand name: Levaquin
Synonyms: Levofloxacin
Generic Name: paclitaxel
Brand name: Onxol, Taxol
Synonyms: Paclitaxel, PACLitaxel (Conventional)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Levofloxacin (Systemic)-Paclitaxel Intravenous
- Levofloxacin (Systemic)-Paclitaxel Novaplus
- Levofloxacin (Systemic)-Paclitaxel protein-bound
- Levofloxacin (Systemic)-Paclitaxel protein-bound Intravenous
- Levofloxacin (Systemic)-Pacnex
- Levofloxacin (Systemic)-Pacnex LP
- Paclitaxel Concentrate Injection-Levofloxacin injection
- Paclitaxel Concentrate Injection-Levofloxacin Injection Concentrate
- Paclitaxel Concentrate Injection-Levofloxacin Intravenous
- Paclitaxel Concentrate Injection-Levofloxacin Oral Solution
- Paclitaxel Concentrate Injection-Levofloxacin Tablets
- Paclitaxel Concentrate Injection-Levoleucovorin