Levoleucovorin Calcium and Methotrexate Tablets
Determining the interaction of Levoleucovorin Calcium and Methotrexate Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic effects of methotrexate. The proposed mechanism involves pharmacodynamic antagonism and/or competitive inhibition at the receptor site. MANAGEMENT: Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives. References "Product Information. Methotrexate Sodium (methotrexate)." Teva Pharmaceuticals (formerly IVAX), Miami, FL. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Cerner Multum, Inc. "Australian Product Information." O 0
Professional:MONITOR: Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic effects of methotrexate. The proposed mechanism involves pharmacodynamic antagonism and/or competitive inhibition at the receptor site.
MANAGEMENT: Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives.
- "Product Information. Methotrexate Sodium (methotrexate)." Teva Pharmaceuticals (formerly IVAX), Miami, FL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: levoleucovorin
Brand name: Fusilev, Khapzory
Synonyms: Levoleucovorin, LEVOleucovorin
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Levoleucovorin Calcium-Methoxsalen
- Levoleucovorin Calcium-Methoxsalen (Systemic)
- Levoleucovorin Calcium-Methoxsalen (Topical)
- Levoleucovorin Calcium-Methoxsalen Extracorporeal Solution
- Levoleucovorin Calcium-Methoxsalen Hard-Gelatin Capsules
- Levoleucovorin Calcium-Methoxsalen injection
- Methotrexate Tablets-Levoleucovorin Intravenous
- Methotrexate Tablets-Levomefolate, Calcium Acetylcysteine and Mecobalamin Algal
- Methotrexate Tablets-Levomilnacipran
- Methotrexate Tablets-Levomilnacipran Hydrochloride
- Methotrexate Tablets-Levonest
- Methotrexate Tablets-Levonorgestrel