Levoleucovorin Calcium and NovoLog FlexPen

• Generic Name: levoleucovorin
• Dosage Forms: n.a.
• Other Brand Names: Fusilev, Khapzory

IV rescue therapy after high-dose methotrexate therapy (to control the duration of exposure of sensitive cells to methotrexate) for treatment of osteosarcoma (designated an orphan drug by FDA for this use).

Antidote to diminish the toxicity and counteract the effects of unintentional overdosage of methotrexate (e.g., resulting from impaired elimination) and other folic acid antagonists (designated an orphan drug by FDA for this use).

In combination with fluorouracil for the palliative treatment of advanced-stage colorectal cancer.

Has been studied for treatment of advanced-stage colorectal cancer in combination with fluorouracil and other agents (i.e., irinotecan, oxaliplatin). However, use in such combination regimens not fully established.

Manufacturer states that levoleucovorin should not be used for the treatment of pernicious anemia and megaloblastic anemias secondary to lack of vitamin B12; such use may alleviate hematologic manifestations while allowing neurologic complications to progress.

• Generic Name: insulin aspart
• Dosage Forms: n.a.
• Other Brand Names: Fiasp, NovoLog, NovoLog FlexPen, NovoLog PenFill, NovoLOG FlexTouch, Fiasp PenFill, Fiasp FlexTouch

Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. NovoLog FlexPen is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours.

NovoLog FlexPen is used to improve blood sugar control in adults and children with diabetes mellitus. NovoLog FlexPen is sometimes used together with a long-acting or intermediate-acting insulin.

NovoLog FlexPen may also be used for purposes not listed in this medication guide.