Levomilnacipran Hydrochloride and Levonorgestrel intrauterine system

• Generic Name: levomilnacipran
• Dosage Forms: n.a.
• Other Brand Names: Fetzima

Treatment of major depressive disorder in adults.

APA states that effectiveness of antidepressants is generally comparable between and within classes of medications, including SSRIs, SNRIs, TCAs, MAO inhibitors, and other antidepressants (e.g., bupropion, mirtazapine, trazodone). Choose antidepressant based mainly on the following factors: patient preference; nature of prior response to medication; safety, tolerability, and anticipated adverse effects; concurrent psychiatric and medical conditions; specific properties of the medication (e.g., half-life, actions on CYP isoenzymes, other drug interactions); and cost. For most patients, an SSRI, SNRI, mirtazapine, or bupropion is considered optimal.

Fibromyalgia

Levomilnacipran is the more active 1S,2R-enantiomer of racemic milnacipran (Savella), which is FDA-labeled for use in the management of fibromyalgia.

Manufacturer states that levomilnacipran (Fetzima) is not approved for the management of fibromyalgia; efficacy and safety of the drug for this use not established.

• Generic Name: levonorgestrel
• Dosage Forms: n.a.
• Other Brand Names: EContra EZ, Fallback Solo, My Way, Next Choice, Opcicon One-Step, Plan B One-Step, React, Aftera, EContra One-Step, My Choice, My Way, New Day, Next Choice One Dose, Take Action, Kyleena, Liletta, Mirena, Skyla

Levonorgestrel is a female hormone that can cause changes in your cervix, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus. Levonorgestrel intrauterine system is a plastic device that is placed in the uterus where it slowly releases the hormone to prevent pregnancy for 3 to 6 years.

Levonorgestrel intrauterine system is used to prevent pregnancy for up to 6 years. You may use this device whether you have children or not. Mirena is also used to treat heavy menstrual bleeding in women who choose to use an intrauterine form of birth control.

Levonorgestrel is a progestin hormone and does not contain estrogen. The intrauterine device (IUD) releases levonorgestrel in the uterus, but only small amounts of the hormone reach the bloodstream. Levonorgestrel intrauterine system should not be used as emergency birth control.

Levonorgestrel intrauterine system may also be used for purposes not listed in this medication guide.