Levomilnacipran Hydrochloride and Tikosyn

• Generic Name: levomilnacipran
• Dosage Forms: n.a.
• Other Brand Names: Fetzima

Treatment of major depressive disorder in adults.

APA states that effectiveness of antidepressants is generally comparable between and within classes of medications, including SSRIs, SNRIs, TCAs, MAO inhibitors, and other antidepressants (e.g., bupropion, mirtazapine, trazodone). Choose antidepressant based mainly on the following factors: patient preference; nature of prior response to medication; safety, tolerability, and anticipated adverse effects; concurrent psychiatric and medical conditions; specific properties of the medication (e.g., half-life, actions on CYP isoenzymes, other drug interactions); and cost. For most patients, an SSRI, SNRI, mirtazapine, or bupropion is considered optimal.

Fibromyalgia

Levomilnacipran is the more active 1S,2R-enantiomer of racemic milnacipran (Savella), which is FDA-labeled for use in the management of fibromyalgia.

Manufacturer states that levomilnacipran (Fetzima) is not approved for the management of fibromyalgia; efficacy and safety of the drug for this use not established.

• Generic Name: dofetilide
• Dosage Forms: capsule
• Other Brand Names: Tikosyn

Tikosyn is a heart rhythm medicine, also called an antiarrhythmic.

Tikosyn is used to help keep the heart beating normally in people with certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart). This medicine is used in people with atrial fibrillation or atrial flutter.

Tikosyn may also be used for purposes not listed in this medication guide.