Levomilnacipran Hydrochloride and Voltaren Gel

• Generic Name: levomilnacipran
• Dosage Forms: n.a.
• Other Brand Names: Fetzima

Treatment of major depressive disorder in adults.

APA states that effectiveness of antidepressants is generally comparable between and within classes of medications, including SSRIs, SNRIs, TCAs, MAO inhibitors, and other antidepressants (e.g., bupropion, mirtazapine, trazodone). Choose antidepressant based mainly on the following factors: patient preference; nature of prior response to medication; safety, tolerability, and anticipated adverse effects; concurrent psychiatric and medical conditions; specific properties of the medication (e.g., half-life, actions on CYP isoenzymes, other drug interactions); and cost. For most patients, an SSRI, SNRI, mirtazapine, or bupropion is considered optimal.

Fibromyalgia

Levomilnacipran is the more active 1S,2R-enantiomer of racemic milnacipran (Savella), which is FDA-labeled for use in the management of fibromyalgia.

Manufacturer states that levomilnacipran (Fetzima) is not approved for the management of fibromyalgia; efficacy and safety of the drug for this use not established.

• Generic Name: diclofenac topical
• Dosage Forms: gel
• Other Brand Names: Pennsaid, Solaraze, Voltaren Topical, DST Plus Pak, Diclozor, Voltaren, Flector Patch, Klofensaid II, Vopac MDS, Xrylix, Flector, Licart

Voltaren Gel contains diclofenac, a nonsteroidal anti-inflammatory drug (NSAID). Diclofenac works by reducing substances in the body that cause pain and inflammation.

Voltaren Gel is used to treat joint pain caused by osteoarthritis in the hands, wrists, elbows, knees, ankles, or feet.

Voltaren Gel may not be effective in treating arthritis pain elsewhere in the body.