Levomilnacipran Hydrochloride and Vonvendi

• Generic Name: levomilnacipran
• Dosage Forms: n.a.
• Other Brand Names: Fetzima

Treatment of major depressive disorder in adults.

APA states that effectiveness of antidepressants is generally comparable between and within classes of medications, including SSRIs, SNRIs, TCAs, MAO inhibitors, and other antidepressants (e.g., bupropion, mirtazapine, trazodone). Choose antidepressant based mainly on the following factors: patient preference; nature of prior response to medication; safety, tolerability, and anticipated adverse effects; concurrent psychiatric and medical conditions; specific properties of the medication (e.g., half-life, actions on CYP isoenzymes, other drug interactions); and cost. For most patients, an SSRI, SNRI, mirtazapine, or bupropion is considered optimal.

Fibromyalgia

Levomilnacipran is the more active 1S,2R-enantiomer of racemic milnacipran (Savella), which is FDA-labeled for use in the management of fibromyalgia.

Manufacturer states that levomilnacipran (Fetzima) is not approved for the management of fibromyalgia; efficacy and safety of the drug for this use not established.

• Generic Name: von willebrand factor
• Dosage Forms: n.a.
• Other Brand Names: Vonvendi, Wilfactin

Vonvendi (von Willebrand factor) is a naturally occurring protein in the blood that helps blood to clot. People with an inherited blood-clotting disorder called von Willebrand disease do not have enough of this protein in their blood. A lack of von Willebrand factor can cause uncontrolled bleeding.

Vonvendi is used to control bleeding episodes in adults with von Willebrand disease.

Vonvendi may also be used for purposes not listed in this medication guide.