Levothyroxine and Tegretol (Carbamazepine Oral Suspension)
Determining the interaction of Levothyroxine and Tegretol (Carbamazepine Oral Suspension) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using carBAMazepine together with levothyroxine can decrease the effects of levothyroxine. This can cause fatigue, weight gain, constipation, and low blood pressure. Talk with your doctor before using carBAMazepine while you are using levothyroxine. You may need a dose adjustment and may need to check your thyroid levels more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Carbamazepine and phenytoin may decrease exogenous thyroid plasma concentrations resulting in elevated thyroid stimulating hormone (TSH) and possible exacerbation of hypothyroidism. The mechanism may be induction of hepatic CYP450 enzymes responsible for thyroxine (T4) and triiodothyronine (T3) metabolism. In addition, T3 and T4 may be displaced from thyroxine binding globulin by phenytoin. Clinical data are limited.
MANAGEMENT: Clinical monitoring of patient response, including laboratory serum TSH concentrations, is recommended. Adjustment of the thyroid replacement dosage may be indicated when initiating or discontinuing phenytoin or carbamazepine therapy.
- "Multum Information Services, Inc. Expert Review Panel"
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: levothyroxine
Brand name: Levoxyl, Synthroid, Tirosint, Unithroid, Euthyrox, Levothroid, Tirosint-Sol
Synonyms: n.a.
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: Tegretol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Levothyroxine-Tegretol (Carbamazepine Tablets)
- Levothyroxine-Tegretol XR
- Levothyroxine-Tegrin Medicated
- Levothyroxine-Tegsedi
- Levothyroxine-Tekamlo
- Levothyroxine-Tekral Tablets
- Tegretol (Carbamazepine Oral Suspension)-Levothyroxine and Liothyronine Tablets
- Tegretol (Carbamazepine Oral Suspension)-Levothyroxine Capsules
- Tegretol (Carbamazepine Oral Suspension)-Levothyroxine Injection
- Tegretol (Carbamazepine Oral Suspension)-Levothyroxine Injection Solution
- Tegretol (Carbamazepine Oral Suspension)-Levothyroxine Oral Solution
- Tegretol (Carbamazepine Oral Suspension)-Levothyroxine oral/injection