Levothyroxine Capsules and Mephobarbital
Determining the interaction of Levothyroxine Capsules and Mephobarbital and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using mephobarbital together with levothyroxine can decrease the effects of mephobarbital. This can cause fatigue, weight gain, constipation, and low blood pressure. Talk with your doctor before using these medications together, and report any side effects promptly. You may need a dose adjustment or thyroid tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Barbiturates may decrease exogenous thyroid plasma concentrations resulting in elevated thyroid stimulating hormone (TSH) and exacerbation of hypothyroidism. The mechanism may be induction of hepatic CYP450 enzymes responsible for thyroxine (T4) and triiodothyronine (T3) metabolism. Clinical data are limited.
MANAGEMENT: Clinical monitoring of patient response, including laboratory serum TSH concentrations, is recommended. Adjustment of thyroid replacement dosage may be indicated when initiating or discontinuing barbiturate therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Multum Information Services, Inc. Expert Review Panel"
Generic Name: levothyroxine
Brand name: Levoxyl, Synthroid, Tirosint, Unithroid, Euthyrox, Levothroid, Tirosint-Sol
Synonyms: Levothyroxine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Levothyroxine Capsules-Mepron
- Mephobarbital-Levothyroxine Injection
- Mephobarbital-Levothyroxine Injection Solution
- Mephobarbital-Levothyroxine Oral Solution
- Mephobarbital-Levothyroxine oral/injection
- Mephobarbital-Levothyroxine Sodium
- Mephobarbital-Levothyroxine Tablets