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Levothyroxine Sodium and Methimazole

Determining the interaction of Levothyroxine Sodium and Methimazole and the possibility of their joint administration.

Check result:

Levothyroxine Sodium <> Methimazole

Relevance: 15.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using levothyroxine together with methIMAzole. Using these medications together may decrease the effects of levothyroxine. MethIMAzole decreases thyroid hormone and may cause your body to produce too low of levels of thyroid hormone. Therefore, the use of methIMAzole and levothyroxine should generally be avoided due to their opposing properties. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Antithyroid agents such as methimazole and propylthiouracil can affect the therapeutic response to thyroid hormone therapy. These agents decrease thyroid hormone secretion, which may result in hypothyroidism. Conversely, thyroid hormone therapy can antagonize the pharmacologic effects of antithyroid agents by supplying an exogenous source of the hormone.

MANAGEMENT: Concomitant use of antithyroid agents and thyroid hormones should generally be avoided due to mutually negating effects.

References

"Product Information. Synthroid (levothyroxine)." Abbott Pharmaceutical, Abbott Park, IL.

Levothyroxine Sodium

Generic Name: levothyroxine

Brand name: Levothroid, Levoxyl, Synthroid, Unithroid, Tirosint, Euthyrox, Tirosint-Sol

Synonyms: Levothyroxine

What is Levothyroxine Sodium?

Methimazole

Generic Name: methimazole

Brand name: Tapazole, Northyx

Synonyms: n.a.

What is Methimazole?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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