Levothyroxine Sodium and Tezacaftor and Ivacaftor

• Generic Name: levothyroxine
• Dosage Forms: n.a.
• Other Brand Names: Levothroid, Levoxyl, Synthroid, Unithroid, Tirosint, Euthyrox, Tirosint-Sol

Used orally as replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. Specific indications include subclinical hypothyroidism and primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) hypothyroidism.

Considered drug of choice for the treatment of congenital hypothyroidism (cretinism).

Used IV for treatment of myxedema coma.

Has been used IV in other conditions when rapid thyroid replacement is required; however, this is not an FDA-labeled use for the currently available injection.

Treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto’s thyroiditis), and multinodular goiter.

Adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

Efficacy of TSH suppression for benign nodular disease remains controversial.

See Unlabeled Uses under Cautions.

• Generic Name: ivacaftor / tezacaftor
• Dosage Forms: n.a.
• Other Brand Names: Symdeko, Symdeko 4-Week

• It is used to treat cystic fibrosis.