Lidocaine (Systemic) and Nexiclon XR
Determining the interaction of Lidocaine (Systemic) and Nexiclon XR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Clonidine prolongs the duration of lidocaine anesthesia in peripheral and central neuraxial blocks. Data have been conflicting as to whether the mechanism is pharmacokinetic or pharmacodynamic.
- Kopacz DJ, Bernards CM "Effect of Clonidine on Lidocaine Clearance In Vivo: A Microdialysis Study in Humans." Anesthesiology 95 (2001): 1371-1376
- Inomata S, Tanaka E, Miyabe M, et al. "Plasma Lidocaine Concentrations During Continuous Thoracic Epidural Anesthesia After Clonidine Premedication in Children." Anesth Analg 93 (2001): 1147-1151
Generic Name: lidocaine
Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine
Synonyms: Lidocaine injection
Generic Name: clonidine
Brand name: Catapres, Catapres-TTS, Duraclon, Kapvay, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3
Synonyms: Nexiclon XR (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lidocaine (Systemic)-Nexiclon XR Suspension
- Lidocaine (Systemic)-Nexium
- Lidocaine (Systemic)-Nexium (Esomeprazole Delayed-Release Capsules)
- Lidocaine (Systemic)-Nexium (Esomeprazole Powder for Suspension)
- Lidocaine (Systemic)-Nexium 24HR (Esomeprazole Delayed-Release Capsules)
- Lidocaine (Systemic)-NexIUM 24HR (Esomeprazole Delayed-Release Tablets)
- Nexiclon XR-Lidocaine Aerosol
- Nexiclon XR-Lidocaine and Benzalkonium
- Nexiclon XR-Lidocaine and Dextrose
- Nexiclon XR-Lidocaine and Dextrose Intraspinal
- Nexiclon XR-Lidocaine and Epinephrine
- Nexiclon XR-Lidocaine and Epinephrine Injection