Lincomycin Injection and Synalgos-DC Oral

• Generic Name: lincomycin
• Dosage Forms: injection, solution
• Other Brand Names: Lincocin, Lincorex, L-Mycin, Bactramycin

Treatment of serious infections caused by susceptible staphylococci, Streptococcus pneumoniae, and other streptococci. Because of more potent antibacterial activity, clindamycin usually preferred when a lincosamide antibiotic indicated for treatment of these infections.

Reserve for treatment of serious infections when less toxic alternatives cannot be used (e.g., penicillin-allergic patients or other patients for whom a penicillin is inappropriate). Has been associated with potentially fatal colitis (see Superinfection/Clostridium difficile-associated Diarrhea and Colitis [CDAD] under Cautions); consider nature of the infection and suitability of less toxic alternatives (e.g., erythromycin).

May be used concomitantly with other anti-infectives when indicated.

Certain infections may require incision and drainage or other indicated surgical procedures in addition to anti-infective treatment; use of lincomycin does not eliminate need for surgical procedures when indicated.

Do not use for treatment of meningitis because of inadequate CNS penetration following parenteral administration.

• Generic Name: aspirin / caffeine / dihydrocodeine
• Dosage Forms: capsule
• Other Brand Names: Synalgos-DC

Aspirin, caffeine, and dihydrocodeine combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated.

Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce fever in patients. Caffeine is a CNS stimulant that is used together with pain relievers to increase their effect. It has also been used for migraine headaches. Dihydrocodeine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

When dihydrocodeine is used for a long time or in large doses, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program.